Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome.

Vascular Ehlers-Danlos syndrome (vEDS) is a dominantly inherited connective tissue disorder caused by mutations in the COL3A1 gene that encodes type III collagen (COLLIII), which is the major expressed collagen in blood vessels and hollow organs.The majority of disease-causing variants in COL3A1 are glycine substitutions and in-frame splice mutatio

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Mosaic Technology in the Armenian Chapel Birds Mosaic, Jerusalem: Characterizing the Polychrome Hidden Sinopia

Since the Hellenistic period, preparatory drawings known as sinopiae were employed as guidelines for mosaicists in creating mosaics.The sinopiae served as the basis for style and content, facilitating the placement of colored tesserae in the supporting mortar.The technology of the mosaic and pigments used reflect the capacity of the mosaic workshop

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Life history strategy dictates thermal preferences across the diel cycle and in response to starvation in variable field crickets, Gryllus lineaticeps

Insects behaviorally thermoregulate across the diel cycle, and their preferred microhabitats change based on current resources available and the thermal performance optima of traits.Specific combinations of traits being prioritized are set by life history strategies, making here life history an important intrinsic determinant of thermal preferences

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Weaving construction software system

The construction methods within the Desint system are organized into three distinct groups, each catering to specific aspects of the weaving process.These groups delineate the procedures involved in creating woven patterns and are selected based on the type of the initial element required to achieve the final desired weave.This group encompasses co

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